Technology Process of (2S,3R,6S,8R)-8-[N-methyl-N-(toluene-4-sulfonyl)amino]-3,6-epoxy-2-methylundecan-1-ol
There total 14 articles about (2S,3R,6S,8R)-8-[N-methyl-N-(toluene-4-sulfonyl)amino]-3,6-epoxy-2-methylundecan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 89 percent / n-BuLi / -78 °C
2: 100 percent / HCO2NH4; HCO2H / Pd(OH)2/C
3: 91 percent / Et3N; DMAP
4: 100 percent / NaH
5: 94 percent / LiAlH4 / diethyl ether
6: 95 percent / (COCl)2; DMSO; Et3N
7: 64 percent / SnCl4 / -78 °C
8: 43 percent / SnCl4
9: 94 percent / Bu3SnH / AIBN
10: 98 percent / H2 / Pd/C / ethanol
With
dmap; lithium aluminium tetrahydride; n-butyllithium; formic acid; oxalyl dichloride; hydrogen; tri-n-butyl-tin hydride; ammonium formate; tin(IV) chloride; sodium hydride; dimethyl sulfoxide; triethylamine;
palladium dihydroxide; palladium on activated charcoal; 2,2'-azobis(isobutyronitrile);
In
diethyl ether; ethanol;
1: conjugate addition / 2: transfer hydrogenolysis / 4: methylation / 5: reduction / 10: hydrogenolysis;
DOI:10.1016/S0040-4039(01)00921-2
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 100 percent / HCO2NH4; HCO2H / Pd(OH)2/C
2: 91 percent / Et3N; DMAP
3: 100 percent / NaH
4: 94 percent / LiAlH4 / diethyl ether
5: 95 percent / (COCl)2; DMSO; Et3N
6: 64 percent / SnCl4 / -78 °C
7: 43 percent / SnCl4
8: 94 percent / Bu3SnH / AIBN
9: 98 percent / H2 / Pd/C / ethanol
With
dmap; lithium aluminium tetrahydride; formic acid; oxalyl dichloride; hydrogen; tri-n-butyl-tin hydride; ammonium formate; tin(IV) chloride; sodium hydride; dimethyl sulfoxide; triethylamine;
palladium dihydroxide; palladium on activated charcoal; 2,2'-azobis(isobutyronitrile);
In
diethyl ether; ethanol;
1: transfer hydrogenolysis / 3: methylation / 4: reduction / 9: hydrogenolysis;
DOI:10.1016/S0040-4039(01)00921-2
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 91 percent / Et3N; DMAP
2: 100 percent / NaH
3: 94 percent / LiAlH4 / diethyl ether
4: 95 percent / (COCl)2; DMSO; Et3N
5: 64 percent / SnCl4 / -78 °C
6: 43 percent / SnCl4
7: 94 percent / Bu3SnH / AIBN
8: 98 percent / H2 / Pd/C / ethanol
With
dmap; lithium aluminium tetrahydride; oxalyl dichloride; hydrogen; tri-n-butyl-tin hydride; tin(IV) chloride; sodium hydride; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal; 2,2'-azobis(isobutyronitrile);
In
diethyl ether; ethanol;
2: methylation / 3: reduction / 8: hydrogenolysis;
DOI:10.1016/S0040-4039(01)00921-2
