L-erythro-N^α,N^im-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester

Base Information

• Chemical Name: L-erythro-N^α,N^im-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester
• CAS No.: 83044-04-6
• Molecular Formula: C₂₃H₃₁N₃O₇
• Molecular Weight: 461.515
• Mol file: 83044-04-6.mol

Synonyms:L-erythro-N^α,N^im-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester

Chemical Property of L-erythro-N^α,N^im-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of L-erythro-N^α,N^im-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester

There total 1 articles about L-erythro-N^α,N^im-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

phenyldiazomethane (908094-04-2) + Nα,Nim-bis(tert-butoxycarbonyl)-erythro-β-hydroxy-L-histidine (82692-03-3) → L-erythro-Nα,Nim-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester (83044-04-6)

Guidance literature:

DOI:10.1021/ja9819458

Reference yield: 25.0%

L-erythro-Nα,Nim-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester (83044-04-6) + Acetic acid (2R,3S,4S,5R,6R)-5-acetoxy-6-acetoxymethyl-2-((2R,3S,4S,5R,6S)-6-acetoxymethyl-4,5-bis-benzyloxy-2-chloro-tetrahydro-pyran-3-yloxy)-4-acetylcarbamoyloxy-tetrahydro-pyran-3-yl ester (83060-57-5) → C55H66N4O21 (83060-58-6)

Guidance literature:

With silver trifluoromethanesulfonate; tetramethylurea; In 1,2-dichloro-ethane; at 45 ℃; for 12h;

DOI:10.1021/ja00384a067

Reference yield: 12.0%

L-erythro-Nα,Nim-di-tert-butoxycarbonyl-β-hydroxyhistidine benzyl ester (83044-04-6) + Acetic acid (2S,3R,4S,5S,6R)-3,4-bis-benzyloxy-6-chloro-5-((2R,3S,4S,5R,6R)-3,5-diacetoxy-6-acetoxymethyl-4-carbamoyloxy-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-2-ylmethyl ester (217180-01-3) → C53H64N4O20 (217180-09-1) + C58H72N4O22 (217180-08-0)

Guidance literature:

With silver trifluoromethanesulfonate; tetramethylurea; In 1,2-dichloro-ethane; at 48 ℃; for 22h;

DOI:10.1021/ja9819458

upstream raw materials:

phenyldiazomethane

N^α,N^im-bis(tert-butoxycarbonyl)-erythro-β-hydroxy-L-histidine

Downstream raw materials:

C₅₅H₆₆N₄O₂₁

C₄₁H₅₈N₄O₂₄

C₅₃H₆₄N₄O₂₀

C₅₈H₇₂N₄O₂₂