2-(S)-{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-propionic acid

Base Information

Chemical Name:2-(S)-{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-propionic acid
CAS No.:1175094-51-5
Molecular Formula:C₂₅H₁₉NO₇
Molecular Weight:445.428
Hs Code.:

Synonyms:2-(S)-{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-propionic acid

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Chemical Property of 2-(S)-{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-propionic acid

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Technology Process of 2-(S)-{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-propionic acid

There total 5 articles about 2-(S)-{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56-41-7,25191-17-7,18875-37-1
L-alanin

: 1175095-08-5
4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carboxylic acid methyl ester

: 1175094-51-5
2-(S)-{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-propionic acid

Guidance literature:: L-alanin; 4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carboxylic acid methyl ester; With sodium methylate; In methanol; 2-methoxy-ethanol; for 16h; Reflux;

With hydrogenchloride; In water;

Reference yield:

: 1666-28-0
4-bromosalicylic acid

: 1175094-51-5
2-(S)-{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / water / 1 h / 100 °C

2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / tetrahydrofuran / 4 - 20 °C

2.2: 2 h / Cooling

2.3: 2 h / Reflux

3.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2.5 h / Reflux

4.1: sodium methylate / methanol; 2-methoxy-ethanol / 16 h / Reflux

With sulfuric acid; sodium methylate; sodium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; 2-methoxy-ethanol; water;

Reference yield:

: 51067-38-0
4-phenoxyphenylboronic acid

: 1175094-51-5
2-(S)-{[4-hydroxy-2-oxo-7-(4-phenoxy-phenyl)-2H-chromene-3-carbonyl]-amino}-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2.5 h / Reflux

2: sodium methylate / methanol; 2-methoxy-ethanol / 16 h / Reflux

With sodium methylate; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; 2-methoxy-ethanol; water;