5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carboxylic acid

Base Information

Chemical Name:5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carboxylic acid
CAS No.:1467058-05-4
Molecular Formula:C₂₀H₁₉NO₃
Molecular Weight:321.376
Hs Code.:

Synonyms:5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carboxylic acid

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Chemical Property of 5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carboxylic acid

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Technology Process of 5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carboxylic acid

There total 6 articles about 5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1467060-65-6
5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carbaldehyde

: 1467058-05-4
5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carboxylic acid

Guidance literature:: With sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene; In tetrahydrofuran; water; tert-butyl alcohol; at 20 ℃; for 62h;

Reference yield:

: 19936-14-2
1-(4-bromophenyl)cyclobutan-1-ol

: 1467058-05-4
5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 110 °C / Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; ethanol; toluene / 2 h / 110 °C / Inert atmosphere

3.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate monohydrate / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3.2: 15 h / 20 - 120 °C / Inert atmosphere; Microwave irradiation

4.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; tert-butyl alcohol; tetrahydrofuran / 62 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate monohydrate; potassium phosphate monohydrate; 2-methyl-but-2-ene; potassium acetate; palladium diacetate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene; tert-butyl alcohol;

Reference yield:

: 1467059-89-7
1-(4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)cyclobutan-1-ol

: 1467058-05-4
5-[4-(1-hydroxycyclobutyl)phenyl]-6-methyl-1H-indole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; ethanol; toluene / 2 h / 110 °C / Inert atmosphere

2.1: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium phosphate monohydrate / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere; Sealed tube; Microwave irradiation

2.2: 15 h / 20 - 120 °C / Inert atmosphere; Microwave irradiation

3.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogen phosphate monohydrate / water; tert-butyl alcohol; tetrahydrofuran / 62 h / 20 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium chlorite; sodium dihydrogen phosphate monohydrate; potassium phosphate monohydrate; 2-methyl-but-2-ene; palladium diacetate; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; toluene; tert-butyl alcohol;