1-[3-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-[3-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
• CAS No.: 908350-38-9
• Molecular Formula: C₂₈H₃₄N₂O₅Si
• Molecular Weight: 506.674
• Mol file: 908350-38-9.mol

Synonyms:1-[3-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Chemical Property of 1-[3-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[3-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 1 articles about 1-[3-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butylchlorodiphenylsilane (58479-61-1) + 2'-C-α-allyl-2'-deoxyuridine (151384-09-7) → 1-[3-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione (908350-38-9)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

DOI:10.1055/s-2006-941568

Reference yield: 91.0%

1-[3-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione (908350-38-9) + phenylcarbonochloridothioate (1005-56-7) → thiocarbonic acid O-[4-allyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester (908350-39-0)

Guidance literature:

With pyridine; 1-hydroxy-pyrrolidine-2,5-dione; In toluene; at 80 ℃; for 4h;

DOI:10.1055/s-2006-941568

Reference yield:

1-[3-allyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione (908350-38-9) → 1-[3,4-diallyl-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / N-hydroxysuccinimide; pyridine / toluene / 4 h / 80 °C

2: AIBN; Bu₃SnH / benzene / 14 h

With pyridine; 1-hydroxy-pyrrolidine-2,5-dione; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; benzene;

DOI:10.1055/s-2006-941568

upstream raw materials:

tert-butylchlorodiphenylsilane

2'-C-α-allyl-2'-deoxyuridine

Downstream raw materials:

thiocarbonic acid O-[4-allyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester