L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester

Base Information

• Chemical Name: L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester
• CAS No.: 686256-80-4
• Molecular Formula: C₂₈H₄₀N₃O₅PS₂
• Molecular Weight: 593.748
• Mol file: 686256-80-4.mol

Synonyms:L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester

Chemical Property of L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester

Chemical Property:

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Technology Process of L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester

There total 1 articles about L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-dimethylphosphinothioyl-L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester → L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester (686256-80-4)

Guidance literature:

With hydrogenchloride; at 0 - 20 ℃; Yield given;

DOI:10.1246/bcsj.57.2156

Reference yield: 76.0%

N-(t-butoxycarbonyl)-L-tyrosyl-D-alanylglycine + L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester (686256-80-4) → N-(t-butoxycarbonyl)-L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In chloroform; N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1246/bcsj.57.2156

Reference yield: 68.0%

(allyl)2-L-Tyr(But)-D-Ala-Gly-OH + L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester (686256-80-4) → N,N-diallyl-O-t-butyl-L-tyrosyl-D-alanylglycyl-L-phenylalanyl-L-leucyl-S-dimethylphosphinothioyl-L-cysteine p-methoxybenzyl ester

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In chloroform; 1.) 0 deg C, 1 h, 2.) RT, overnight;

DOI:10.1246/bcsj.57.2156