Technology Process of 4-amino-2-hydroxy-benzoic acid diethylamide
There total 5 articles about 4-amino-2-hydroxy-benzoic acid diethylamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C21H30N2O2Si2;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 2h;
Inert atmosphere;
With
hydrogenchloride;
In
tetrahydrofuran; water;
for 0.5h;
Inert atmosphere;
DOI:10.1055/s-0033-1339794
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
2.2: 0.5 h / Inert atmosphere
With
lithium hexamethyldisilazane; lithium diisopropyl amide;
In
tetrahydrofuran;
DOI:10.1055/s-0033-1339794
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; dmap / dichloromethane / 50 °C / Inert atmosphere
2.1: iron; acetic acid / ethanol / 2 h / 60 °C / Inert atmosphere
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere
4.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 - 20 °C / Inert atmosphere
4.2: 0.5 h / Inert atmosphere
With
dmap; iron; acetic acid; triethylamine; lithium hexamethyldisilazane; lithium diisopropyl amide;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1055/s-0033-1339794
