2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester
CAS No.:262419-10-3
Molecular Formula:C₂₃H₃₂N₂O₇
Molecular Weight:448.516
Hs Code.:

2-(6-<i>tert</i>-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1<i>H</i>-isoindole-5,6-dicarboxylic acid dimethyl ester

Synonyms:2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester

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Chemical Property of 2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester

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Technology Process of 2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester

There total 1 articles about 2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: dimethyl isoindolin-5,6-dicarboxylate

: 262419-10-3
2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;
DOI:10.1021/jo9916481

Reference yield: 95.0%

: 3-amino-2-benzenesulfonylamino-propionic acid tert-butyl ester

: 262419-10-3
2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester

: 6-(2-benzenesulfonylamino-2-tert-butoxycarbonyl-ethylcarbamoyl)-2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5-carboxylic acid

Guidance literature:: 2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester; With lithium hydroxide; water; In tetrahydrofuran; methanol; water; at 25 ℃; for 3h;

3-amino-2-benzenesulfonylamino-propionic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 15h; Further stages.;
DOI:10.1021/jo9916481

Reference yield: 71.0%

: 3-amino-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

: 262419-10-3
2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester

: 2-(6-tert-butoxycarbonylamino-hexanoyl)-6-[2-tert-butoxycarbonyl-2-(2,4,6-trimethyl-benzenesulfonylamino)-ethylcarbamoyl]-2,3-dihydro-1H-isoindole-5-carboxylic acid

Guidance literature:: 2-(6-tert-butoxycarbonylamino-hexanoyl)-2,3-dihydro-1H-isoindole-5,6-dicarboxylic acid dimethyl ester; With lithium hydroxide; water; In tetrahydrofuran; methanol; water; at 25 ℃; for 3h;

3-amino-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester; With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 15h; Further stages.;
DOI:10.1021/jo9916481