tert-butyl 2,2',2''-(10-(2-(4-(hex-5-ynamidomethyl)benzylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

Chemical Name:tert-butyl 2,2',2''-(10-(2-(4-(hex-5-ynamidomethyl)benzylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
CAS No.:1314043-19-0
Molecular Formula:C₄₂H₆₈N₆O₈
Molecular Weight:785.037
Hs Code.:

Synonyms:tert-butyl 2,2',2''-(10-(2-(4-(hex-5-ynamidomethyl)benzylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Chemical Property of tert-butyl 2,2',2''-(10-(2-(4-(hex-5-ynamidomethyl)benzylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

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Technology Process of tert-butyl 2,2',2''-(10-(2-(4-(hex-5-ynamidomethyl)benzylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 2 articles about tert-butyl 2,2',2''-(10-(2-(4-(hex-5-ynamidomethyl)benzylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 53293-00-8
hex-5-ynoic acid

: 1314043-18-9
C₃₆H₆₂N₆O₇

: 1314043-19-0
tert-butyl 2,2',2''-(10-(2-(4-(hex-5-ynamidomethyl)benzylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: hex-5-ynoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.0333333h;

C₃₆H₆₂N₆O₇; In N,N-dimethyl-formamide; for 1h;
DOI:10.1016/j.bmc.2010.12.047

Reference yield:

: 137076-54-1
1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid

: 1314043-19-0
tert-butyl 2,2',2''-(10-(2-(4-(hex-5-ynamidomethyl)benzylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.03 h

1.2: 0.5 h

2.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.03 h

2.2: 1 h

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2010.12.047