Technology Process of (S)-2-(5-methoxy-2-methyl-phenyl)-1-methyl-ethylamine
There total 6 articles about (S)-2-(5-methoxy-2-methyl-phenyl)-1-methyl-ethylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium 10% on activated carbon;
In
ethyl acetate;
for 1h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 20 °C
2: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C
3: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h
With
sodium azide; hydrogen; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrazine hydrate / palladium 10% on activated carbon / 1,2-dimethoxyethane / 52 h / Inert atmosphere; Reflux
2.1: nitrosonium tetrafluoroborate / acetonitrile / -20 - 0 °C
2.2: Cooling with ice
3.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -100 - -90 °C / Inert atmosphere
3.2: -105 - -90 °C
3.3: -90 - 0 °C
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / -10 - 20 °C
5.1: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C
6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 1 h
With
sodium azide; hydrogen; sec.-butyllithium; nitrosonium tetrafluoroborate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; cyclohexane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
