4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid

Base Information

Chemical Name:4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid
CAS No.:1346134-49-3
Molecular Formula:C₃₈H₃₉N₃O₈S₂
Molecular Weight:729.875
Hs Code.:

4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid

Synonyms:4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid

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Chemical Property of 4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid

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Technology Process of 4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid

There total 14 articles about 4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid sodium salt

: 1346134-49-3
4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid

Guidance literature:: With hydrogenchloride; In water; at 20 ℃; for 1h;

Reference yield:

: 1346136-14-8
3-(chlorosulfonyl)benzoic acid 2-(trimethylsilyl)ethyl

: 1346134-49-3
4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

4.2: 2 h / 20 °C

5.1: sodium hydroxide / water; ethanol / Reflux

6.1: hydrogenchloride / water / 1 h / 20 °C

With pyridine; hydrogenchloride; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium carbonate; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1346136-23-9
3-[cyclopropyl(4-ethoxy-4-oxobutyl)sulfamoyl]benzoic acid

: 1346134-49-3
4-{2-[4-({[2-({3-[(3-carboxypropyl)(cyclopropyl)sulfamoyl]benzoyl}amino)-4,5,6,7-tetrahydro-1-benzothiophen-3-yl]carbonyl}amino)phenyl]ethyl}benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

1.2: 2 h / 20 °C

2.1: sodium hydroxide / water; ethanol / Reflux

3.1: hydrogenchloride / water / 1 h / 20 °C

With hydrogenchloride; oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In ethanol; dichloromethane; water;