4-Nitro-benzoic acid (1R,5S)-5-(4-methoxy-benzyloxy)-6-methyl-1-[(R)-1-methyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-heptyl ester

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Chemical Name:4-Nitro-benzoic acid (1R,5S)-5-(4-methoxy-benzyloxy)-6-methyl-1-[(R)-1-methyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-heptyl ester
CAS No.:184104-24-3
Molecular Formula:C₃₆H₄₂N₂O₉
Molecular Weight:646.737
Hs Code.:

Synonyms:4-Nitro-benzoic acid (1R,5S)-5-(4-methoxy-benzyloxy)-6-methyl-1-[(R)-1-methyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-heptyl ester

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Chemical Property of 4-Nitro-benzoic acid (1R,5S)-5-(4-methoxy-benzyloxy)-6-methyl-1-[(R)-1-methyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-heptyl ester

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Technology Process of 4-Nitro-benzoic acid (1R,5S)-5-(4-methoxy-benzyloxy)-6-methyl-1-[(R)-1-methyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-heptyl ester

There total 9 articles about 4-Nitro-benzoic acid (1R,5S)-5-(4-methoxy-benzyloxy)-6-methyl-1-[(R)-1-methyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 184104-23-2
(4R,5S)-3-[(2R,3S,7S)-3-Hydroxy-7-(4-methoxy-benzyloxy)-2,8-dimethyl-nonanoyl]-4-methyl-5-phenyl-oxazolidin-2-one

: 62-23-7
4-nitro-benzoic acid

: 184104-24-3
4-Nitro-benzoic acid (1R,5S)-5-(4-methoxy-benzyloxy)-6-methyl-1-[(R)-1-methyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-heptyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In benzene; at 23 ℃;
DOI:10.1016/0040-4039(96)01653-X

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 184104-24-3
4-Nitro-benzoic acid (1R,5S)-5-(4-methoxy-benzyloxy)-6-methyl-1-[(R)-1-methyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-heptyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 58 percent / TfOH / diethyl ether / 23 °C

2: 98 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: 98 percent / pyridine / 0 °C

4: CuI / diethyl ether / 95 h / 0 °C

5: 1.) 9-BBN; 2.) 30percent H₂O₂, NaOH / 1.) THF, 23 deg C; 2.) THF, H₂O, 23 deg C

6: 94 percent / DMSO, (COCl)2, Et₃N / CH₂Cl₂ / -78 deg C -> 0 deg C

7: 98 percent / Bu₂BOTf, Et₃N / CH₂Cl₂ / -78 °C

8: 67 percent / (i-PrOOC-N=)2, PPh₃ / benzene / 23 °C

With sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; trifluorormethanesulfonic acid; di-isopropyl azodicarboxylate; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane; benzene;
DOI:10.1016/0040-4039(96)01653-X

Reference yield:

: 90244-32-9
(R)-methyl 2-hydroxy-3-methylbutanoate

: 184104-24-3
4-Nitro-benzoic acid (1R,5S)-5-(4-methoxy-benzyloxy)-6-methyl-1-[(R)-1-methyl-2-((4R,5S)-4-methyl-2-oxo-5-phenyl-oxazolidin-3-yl)-2-oxo-ethyl]-heptyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 58 percent / TfOH / diethyl ether / 23 °C

2: 98 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: 98 percent / pyridine / 0 °C

4: CuI / diethyl ether / 95 h / 0 °C

5: 1.) 9-BBN; 2.) 30percent H₂O₂, NaOH / 1.) THF, 23 deg C; 2.) THF, H₂O, 23 deg C

6: 94 percent / DMSO, (COCl)2, Et₃N / CH₂Cl₂ / -78 deg C -> 0 deg C

7: 98 percent / Bu₂BOTf, Et₃N / CH₂Cl₂ / -78 °C

8: 67 percent / (i-PrOOC-N=)2, PPh₃ / benzene / 23 °C

With sodium hydroxide; copper(l) iodide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; trifluorormethanesulfonic acid; di-isopropyl azodicarboxylate; di-n-butylboryl trifluoromethanesulfonate; dihydrogen peroxide; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane; benzene;
DOI:10.1016/0040-4039(96)01653-X