N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Base Information

Chemical Name:N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline
CAS No.:744253-77-8
Molecular Formula:C₂₁H₂₀N₄O₉
Molecular Weight:472.411
Hs Code.:

Synonyms:N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Chemical Property:

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Technology Process of N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

There total 4 articles about N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 744253-84-7
(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

: 99-33-2
3,5-dinitrobenoyl chloride

: 744253-77-8
N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Guidance literature:: With sodium hydroxide; at 20 ℃; for 1.5h;
DOI:10.1055/s-2004-822384

Reference yield:

: 13726-69-7,946610-68-0
(2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid

: 744253-77-8
N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / pyridine / 22 h / 115 °C

2: 73 percent / TFA / CH₂Cl₂ / 0.5 h / 20 °C

3: 65 percent / aq. NaOH / 1.5 h / 20 °C

With pyridine; sodium hydroxide; trifluoroacetic acid; In dichloromethane;
DOI:10.1055/s-2004-822384

Reference yield:

: 54132-75-1
3,5-dimethylphenyl isocyanate

: 744253-77-8
N-(3,5-dinitrobenzoyl)-(4R)-(3,5-dimethylphenylaminocarbonyloxy)-L-proline

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / pyridine / 22 h / 115 °C

2: 73 percent / TFA / CH₂Cl₂ / 0.5 h / 20 °C

3: 65 percent / aq. NaOH / 1.5 h / 20 °C

With pyridine; sodium hydroxide; trifluoroacetic acid; In dichloromethane;
DOI:10.1055/s-2004-822384