C₃₁H₂₇NO₅

Base Information

• Chemical Name: C₃₁H₂₇NO₅
• CAS No.: 1436417-39-8
• Molecular Formula: C₃₁H₂₇NO₅
• Molecular Weight: 493.559
• Mol file: 1436417-39-8.mol

Synonyms:C₃₁H₂₇NO₅

Chemical Property of C₃₁H₂₇NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₁H₂₇NO₅

There total 9 articles about C₃₁H₂₇NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1,3-bis-(4-methoxyphenyl)-2-ethynyl-1-one (65418-71-5) + C14H14INO2 (1436417-38-7) → C31H27NO5 (1436417-39-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; at 65 ℃; for 24h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo400841d

Reference yield:

2-amino-4',6-dimethoxybiphenyl (84251-38-7) → C31H27NO5 (1436417-39-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; Iodine monochloride / water; diethyl ether / 6 h / 0 °C / Darkness

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 24 h / 65 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Iodine monochloride; sodium carbonate; potassium carbonate; In tetrahydrofuran; diethyl ether; water; 2: |Larock Annulation;

DOI:10.1021/jo400841d

Reference yield:

meta-dinitrobenzene (99-65-0) → C31H27NO5 (1436417-39-8)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium tert-butylate; copper(l) chloride / 1,2-dimethoxyethane / 67 °C

2: Hexamethylphosphorous triamide / 20 °C

3: zinc; acetic acid / dichloromethane / 0 °C

4: sodium carbonate; Iodine monochloride / diethyl ether / 0 °C

5: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 24 h / 65 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium tert-butylate; Iodine monochloride; sodium carbonate; potassium carbonate; acetic acid; copper(l) chloride; zinc; Hexamethylphosphorous triamide; In tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; 1: |Ullmann Condensation / 5: |Larock Annulation;

DOI:10.1002/ejoc.201402672

upstream raw materials:

2-amino-4',6-dimethoxybiphenyl

1,3-bis-(4-methoxyphenyl)-2-ethynyl-1-one

C₁₄H₁₄INO₂

meta-dinitrobenzene

Downstream raw materials:

C₄₀H₃₇NO₆

C₄₀H₃₆BrNO₆

C₅₃H₄₆N₂O₇

{7-hydroxy-5-methoxy-1,4-bis-(4-methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-3,6-dihydropyrrolo[2,3-c]carbazol-2-yl}-(4-methoxyphenyl)methanone