3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid hemihydrate

Base Information

Chemical Name:3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid hemihydrate
CAS No.:121653-77-8
Molecular Formula:C₁₅H₁₆N₂O₆
Molecular Weight:320.302
Hs Code.:

Synonyms:3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid hemihydrate

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Chemical Property of 3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid hemihydrate

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Technology Process of 3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid hemihydrate

There total 4 articles about 3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid hemihydrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 121653-74-5
methyl 3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

: 121653-77-8
3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid hemihydrate

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; for 5h;
DOI:10.1021/jm00128a032

Reference yield:

: 622-08-2,1201808-31-2
2-Benzyloxyethanol

: 121653-77-8
3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid hemihydrate

Guidance literature:: Multi-step reaction with 4 steps

1: 5.07 g / benzene / 1.5 h / Heating

2: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

3: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

4: 81 percent / 1 N LiOH / tetrahydrofuran; H₂O / 5 h

With lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; triethylamine; tin(IV) chloride; In tetrahydrofuran; dichloromethane; water; benzene;
DOI:10.1021/jm00128a032

Reference yield:

: 121653-72-3
(2-Benzyloxy-ethoxy)-hydroxy-acetic acid methyl ester

: 121653-77-8
3,4-dihydro-2,4-dioxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid hemihydrate

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

2: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

3: 81 percent / 1 N LiOH / tetrahydrofuran; H₂O / 5 h

With lithium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; triethylamine; tin(IV) chloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/jm00128a032