tert-butyl 4-[4-bromo-2'-(cyclohexylamino)-2,4'-bipyridin-6-yl]piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[4-bromo-2'-(cyclohexylamino)-2,4'-bipyridin-6-yl]piperazine-1-carboxylate
CAS No.:1201674-50-1
Molecular Formula:C₂₅H₃₄BrN₅O₂
Molecular Weight:516.481
Hs Code.:

Synonyms:tert-butyl 4-[4-bromo-2'-(cyclohexylamino)-2,4'-bipyridin-6-yl]piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-[4-bromo-2'-(cyclohexylamino)-2,4'-bipyridin-6-yl]piperazine-1-carboxylate

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Technology Process of tert-butyl 4-[4-bromo-2'-(cyclohexylamino)-2,4'-bipyridin-6-yl]piperazine-1-carboxylate

There total 8 articles about tert-butyl 4-[4-bromo-2'-(cyclohexylamino)-2,4'-bipyridin-6-yl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175422-04-5
2,6-dibromo-4-nitropyridine

: 1201674-50-1
tert-butyl 4-[4-bromo-2'-(cyclohexylamino)-2,4'-bipyridin-6-yl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / 1,4-dioxane / 4 h / 110 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

3: 62 h / 107 °C

4: dmap / dichloromethane; acetonitrile / 4.5 h / 85 °C

5: potassium hydroxide / dimethyl sulfoxide / 1 h / 20 °C

6: phosphorus(V) oxybromide / 1 h / 130 °C

7: triethylamine / dichloromethane / 0.5 h / 20 °C

With sodium carbonate; triethylamine; potassium hydroxide; phosphorus(V) oxybromide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1201674-49-8
(4-bromo-6-piperazin-1-yl[2,4']bipyridinyl-2'-yl)-cyclohexylamine

: 1201674-50-1
tert-butyl 4-[4-bromo-2'-(cyclohexylamino)-2,4'-bipyridin-6-yl]piperazine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm100076w

Reference yield:

: 1201675-68-4
4-(6-bromo-4-nitropyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1201674-50-1
tert-butyl 4-[4-bromo-2'-(cyclohexylamino)-2,4'-bipyridin-6-yl]piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

2: 62 h / 107 °C

3: dmap / dichloromethane; acetonitrile / 4.5 h / 85 °C

4: potassium hydroxide / dimethyl sulfoxide / 1 h / 20 °C

5: phosphorus(V) oxybromide / 1 h / 130 °C

6: triethylamine / dichloromethane / 0.5 h / 20 °C

With sodium carbonate; triethylamine; potassium hydroxide; phosphorus(V) oxybromide; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; acetonitrile;