[2-(4-Chloro-benzyl)-imidazo[4,5-b]pyridin-3-yl]-acetic acid; compound with methanol

Base Information

Chemical Name:[2-(4-Chloro-benzyl)-imidazo[4,5-b]pyridin-3-yl]-acetic acid; compound with methanol
CAS No.:135428-86-3
Molecular Formula:CH₄O*C₁₅H₁₂ClN₃O₂
Molecular Weight:333.774
Hs Code.:

Synonyms:[2-(4-Chloro-benzyl)-imidazo[4,5-b]pyridin-3-yl]-acetic acid; compound with methanol

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Chemical Property of [2-(4-Chloro-benzyl)-imidazo[4,5-b]pyridin-3-yl]-acetic acid; compound with methanol

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Technology Process of [2-(4-Chloro-benzyl)-imidazo[4,5-b]pyridin-3-yl]-acetic acid; compound with methanol

There total 4 articles about [2-(4-Chloro-benzyl)-imidazo[4,5-b]pyridin-3-yl]-acetic acid; compound with methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5470-18-8,34515-82-7
2-Chloro-3-nitropyridine

: 135428-86-3
[2-(4-Chloro-benzyl)-imidazo[4,5-b]pyridin-3-yl]-acetic acid; compound with methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / Et₃N / ethanol / 1.75 h / Heating

2: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

3: 95 percent / Et₃N / tetrahydrofuran / Ambient temperature

4: 2.) aq. KOH / 1.) ethylene glycol, reflux, 1 h, 2.) ethylene glycol, reflux, 1 h

With potassium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00114a007

Reference yield:

: 90559-63-0
N-(3-nitro-2-pyridinyl)glycine ethyl ester

: 135428-86-3
[2-(4-Chloro-benzyl)-imidazo[4,5-b]pyridin-3-yl]-acetic acid; compound with methanol

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

2: 95 percent / Et₃N / tetrahydrofuran / Ambient temperature

3: 2.) aq. KOH / 1.) ethylene glycol, reflux, 1 h, 2.) ethylene glycol, reflux, 1 h

With potassium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm00114a007

Reference yield:

: 118699-22-2
N-(3-amino-2-pyridinyl)glycine ethyl ester

: 135428-86-3
[2-(4-Chloro-benzyl)-imidazo[4,5-b]pyridin-3-yl]-acetic acid; compound with methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N / tetrahydrofuran / Ambient temperature

2: 2.) aq. KOH / 1.) ethylene glycol, reflux, 1 h, 2.) ethylene glycol, reflux, 1 h

With potassium hydroxide; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00114a007