(2S,4'R)-N,N-dimethyl-2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-1-(2-methylphenyl)-2-oxo-ethanamine

Base Information

• Chemical Name: (2S,4'R)-N,N-dimethyl-2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-1-(2-methylphenyl)-2-oxo-ethanamine
• CAS No.: 1259324-91-8
• Molecular Formula: C₂₂H₂₈N₂O₂
• Molecular Weight: 352.477
• Mol file: 1259324-91-8.mol

Synonyms:(2S,4'R)-N,N-dimethyl-2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-1-(2-methylphenyl)-2-oxo-ethanamine

Chemical Property of (2S,4'R)-N,N-dimethyl-2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-1-(2-methylphenyl)-2-oxo-ethanamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (2S,4'R)-N,N-dimethyl-2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-1-(2-methylphenyl)-2-oxo-ethanamine

There total 1 articles about (2S,4'R)-N,N-dimethyl-2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-1-(2-methylphenyl)-2-oxo-ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(4'R)-N-benzyl-N,N-dimethyl-N-([2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-2-oxo]ethyl)ammonium bromide (1259324-89-4) → (2S,4'R)-N,N-dimethyl-2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-1-(2-methylphenyl)-2-oxo-ethanamine (1259324-91-8)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 4h; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2010.09.105

Reference yield: 91.0%

(2S,4'R)-N,N-dimethyl-2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-1-(2-methylphenyl)-2-oxo-ethanamine (1259324-91-8) → (2S,1'R)-2-(dimethylamino)-N-(2'-hydroxy-1'-phenylethyl)-2-(2-methylphenyl)acetamide (1259324-93-0)

Guidance literature:

With hydrogenchloride; In water; for 3h; Reflux;

DOI:10.1016/j.tet.2010.09.105

upstream raw materials:

(4'R)-N-benzyl-N,N-dimethyl-N-([2-(2',2'-dimethyl-4'-phenyl-1',3'-oxazolidin-3'-yl)-2-oxo]ethyl)ammonium bromide

Downstream raw materials:

(2S,1'R)-2-(dimethylamino)-N-(2'-hydroxy-1'-phenylethyl)-2-(2-methylphenyl)acetamide