2,4-dimethoxy-(2'R)-trans-5-<2',5'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine

Base Information

Chemical Name:2,4-dimethoxy-(2'R)-trans-5-<2',5'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine
CAS No.:148553-57-5
Molecular Formula:C₃₀H₂₈N₂O₄
Molecular Weight:480.563
Hs Code.:

Synonyms:2,4-dimethoxy-(2'R)-trans-5-<2',5'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine

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Chemical Property of 2,4-dimethoxy-(2'R)-trans-5-<2',5'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine

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Technology Process of 2,4-dimethoxy-(2'R)-trans-5-<2',5'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine

There total 3 articles about 2,4-dimethoxy-(2'R)-trans-5-<2',5'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 148440-97-5
(5R)-4,5-Dihydro-5-<(triphenylmethoxy)methyl>furan

: 52522-99-3
2,4-dimethoxy-5-iodopyrimidine

: 148441-01-4
2,4-dimethoxy-(2'R)-5-<2',3'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine

: 148553-57-5
2,4-dimethoxy-(2'R)-trans-5-<2',5'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine

Guidance literature:: With triphenyl-arsane; triethylamine; palladium diacetate; In acetonitrile; at 75 ℃; for 10h;
DOI:10.1021/jo00061a034

Reference yield:

: 78158-90-4
(5R)-5-<(triphenylmethoxy)methyl>-γ-butyrolactone

: 148553-57-5
2,4-dimethoxy-(2'R)-trans-5-<2',5'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminum hydride / CH₂Cl₂; tetrahydrofuran / 0.33 h / -78 °C

2: triethylamine, methanesulfonyl chloride / CH₂Cl₂ / 1) -22 deg C, 20 min, 2) to 40 deg C, 3) reflux, 5 h

3: 56 percent / sodium acetate, triethylamine, tetra-n-butylammonium chloride*H₂O / palladium acetate / dimethylformamide / 20 h / Ambient temperature

With tetrabutyl-ammonium chloride; sodium acetate; diisobutylaluminium hydride; methanesulfonyl chloride; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00061a034

Reference yield:

: 637741-83-4
(5R)-5-<(triphenylmethoxy)methyl>-γ-butyrolactol

: 148553-57-5
2,4-dimethoxy-(2'R)-trans-5-<2',5'-dihydro-5'-<(triphenylmethoxy)methyl>-2'-furanyl>pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine, methanesulfonyl chloride / CH₂Cl₂ / 1) -22 deg C, 20 min, 2) to 40 deg C, 3) reflux, 5 h

2: 56 percent / sodium acetate, triethylamine, tetra-n-butylammonium chloride*H₂O / palladium acetate / dimethylformamide / 20 h / Ambient temperature

With tetrabutyl-ammonium chloride; sodium acetate; methanesulfonyl chloride; triethylamine; palladium diacetate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00061a034