4-cyclohexyl-4-hydroxy-2-methylene-N-(2-methoxyphenyl)butanamide

Base Information

• Chemical Name: 4-cyclohexyl-4-hydroxy-2-methylene-N-(2-methoxyphenyl)butanamide
• CAS No.: 77407-49-9
• Molecular Formula: C₁₈H₂₅NO₃
• Molecular Weight: 303.401
• Mol file: 77407-49-9.mol

Synonyms:4-cyclohexyl-4-hydroxy-2-methylene-N-(2-methoxyphenyl)butanamide

Chemical Property of 4-cyclohexyl-4-hydroxy-2-methylene-N-(2-methoxyphenyl)butanamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-cyclohexyl-4-hydroxy-2-methylene-N-(2-methoxyphenyl)butanamide

There total 2 articles about 4-cyclohexyl-4-hydroxy-2-methylene-N-(2-methoxyphenyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-(2-methoxyphenyl)-2-<(tributylstannyl)methyl>propenamide (101566-91-0) + cyclohexanecarbaldehyde (2043-61-0) → 4-cyclohexyl-4-hydroxy-2-methylene-N-(2-methoxyphenyl)butanamide (77407-49-9)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -78 - 0 ℃; for 4h;

DOI:10.1021/jo00360a038

Reference yield:

N-(o-methoxyphenyl)-2-methylpropenamide (13910-91-3) + cyclohexanecarbaldehyde (2043-61-0) → 4-cyclohexyl-4-hydroxy-2-methylene-N-(2-methoxyphenyl)butanamide (77407-49-9)

Guidance literature:

With n-butyllithium; potassium tert-butylate; Yield given. Multistep reaction; 1.) THF, -78 degC, 40 min., 2.) THF, H₂O;

DOI:10.1246/cl.1980.1567

Reference yield: 88.0%

4-cyclohexyl-4-hydroxy-2-methylene-N-(2-methoxyphenyl)butanamide (77407-49-9) → (RS)-5-cyclohexyl-3-methylenedihydrofuran-2(3H)-one (101567-04-8,121842-19-1,77407-51-3)

Guidance literature:

With hydrogenchloride; In water;

DOI:10.1246/cl.1980.1567

upstream raw materials:

N-(o-methoxyphenyl)-2-methylpropenamide

cyclohexanecarbaldehyde

N-(2-methoxyphenyl)-2-<(tributylstannyl)methyl>propenamide

Downstream raw materials:

(RS)-5-cyclohexyl-3-methylenedihydrofuran-2(3H)-one