4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Base Information

Chemical Name:4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine
CAS No.:1583284-77-8
Molecular Formula:C₁₅H₁₅ClN₄OS
Molecular Weight:334.829
Hs Code.:

Synonyms:4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Suppliers and Price of 4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

There total 3 articles about 4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 85426-79-5
4-chloro-6-methylmercapto-1H-pyrazolo[3,4-d]pyrimidine

: 2979-22-8
2-methoxy-2-phenylethanol

: 1583284-77-8
4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 4 - 100 ℃; Cooling with ice; Inert atmosphere; Microwave irradiation;
DOI:10.1021/co500004e

Reference yield:

: 1979-98-2
4,6-dihydroxy-2-methylmercaptopyrimidine

: 1583284-77-8
4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 1 h / 20 °C / Cooling with ice; Inert atmosphere

1.2: 12 h / Reflux; Inert atmosphere

2.1: triethylamine; hydrazine hydrate / 1,4-dioxane / 5 h / 20 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 - 100 °C / Cooling with ice; Inert atmosphere; Microwave irradiation

With di-isopropyl azodicarboxylate; hydrazine hydrate; triethylamine; triphenylphosphine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/co500004e

Reference yield:

: 33097-11-9
4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde

: 1583284-77-8
4-chloro-1-(2-methoxy-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; hydrazine hydrate / 1,4-dioxane / 5 h / 20 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 - 100 °C / Cooling with ice; Inert atmosphere; Microwave irradiation

With di-isopropyl azodicarboxylate; hydrazine hydrate; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/co500004e