cyclohexyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester

Base Information

• Chemical Name: cyclohexyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester
• CAS No.: 1242185-48-3
• Molecular Formula: C₂₈H₃₂N₄O₄
• Molecular Weight: 488.586

Synonyms:cyclohexyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester

Chemical Property of cyclohexyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester

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Technology Process of cyclohexyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester

There total 1 articles about cyclohexyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

N-allyl-2-[(3R)-3-(hydroxymethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl]acetamide (1012860-26-2) + Cyclohexyl isocyanate (3173-53-3) → cyclohexyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester (1242185-48-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.06.010

Reference yield: 70.0%

cyclohexyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester (1242185-48-3) + ethyl acrylate (140-88-5,9003-32-1) → C31H36N4O6 (1402828-85-6)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 100 ℃; for 1h; Microwave irradiation;

DOI:10.1002/cmdc.201200274

Reference yield: 68.0%

cyclohexyl-carbamic acid 1-allylcarbamoylmethyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl-methyl ester (1242185-48-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (R)-methyl 4-(2-(3-((cyclohexylcarbamoyloxy)methyl)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-1-yl)acetamido)but-2-enoate

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 100 ℃; for 2h; Microwave irradiation;

DOI:10.1016/j.bmc.2010.06.010

upstream raw materials:

N-allyl-2-[(3R)-3-(hydroxymethyl)-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-1-yl]acetamide

Cyclohexyl isocyanate

Downstream raw materials:

C₃₁H₃₆N₄O₆

C₃₃H₄₀N₄O₆

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