Technology Process of (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3,5-difluorophenyl)cyclopropanecarboxylic acid
There total 11 articles about (1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-(3,5-difluorophenyl)cyclopropanecarboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene;
In
water; acetone;
at 20 ℃;
for 2h;
DOI:10.1021/acs.jmedchem.5b00217
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lipase acrylic resin from Candida antarctica / tetrahydrofuran / 17 h / 20 °C / Cooling with ice; Enzymatic reaction
2.1: triethylamine / dichloromethane / 1 h / 0 °C
3.1: caesium carbonate / acetonitrile / 4 h / 70 °C
4.1: sodium hydroxide / ethanol; water / 1 h
5.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C
5.2: 1 h / -78 - 20 °C
6.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; acetone / 2 h / 20 °C
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; caesium carbonate; dimethyl sulfoxide; triethylamine; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; acetone; acetonitrile;
5.1: |Swern Oxidation / 5.2: |Swern Oxidation;
DOI:10.1021/acs.jmedchem.5b00217
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: caesium carbonate / acetonitrile / 4 h / 70 °C
2.1: sodium hydroxide / ethanol; water / 1 h
3.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.5 h / -78 °C
3.2: 1 h / -78 - 20 °C
4.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; acetone / 2 h / 20 °C
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; caesium carbonate; dimethyl sulfoxide; sodium hydroxide;
In
ethanol; dichloromethane; water; acetone; acetonitrile;
3.1: |Swern Oxidation / 3.2: |Swern Oxidation;
DOI:10.1021/acs.jmedchem.5b00217
