2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester

Base Information

Chemical Name:2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester
CAS No.:1609398-91-5
Molecular Formula:C₂₀H₂₂FNO₄S
Molecular Weight:391.463
Hs Code.:

Synonyms:2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester

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Chemical Property of 2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester

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Technology Process of 2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester

There total 3 articles about 2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.6%

: 1609398-87-9
(Z)-2-[2-(4-fluorobenzyl)-1,1-dioxido-2H-1,2-benzothiazin-4(3H)-ylidene]acetic acid isopropyl ester

: 1609398-91-5
2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 12h;
DOI:10.1021/jo500338c

Reference yield:

: 29921-57-1
isopropyl 2-bromoacetate

: 1609398-91-5
2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzene / 1 h

1.2: 1 h

2.1: toluene / 12 h / 40 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; toluene; benzene; 2.1: |Wittig Olefination;
DOI:10.1021/jo500338c

Reference yield:

: 110212-61-8
isopropyl 2-(triphenylphosphoranylidene)acetate

: 1609398-91-5
2-[2-(4-fluorobenzyl)-1,1-dioxido-3,4-dihydro-2H-1,2-benzothiazinyl]acetic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 12 h / 40 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; toluene; 1: |Wittig Olefination;
DOI:10.1021/jo500338c