N-<(2S,4S)-4-<2-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester

Base Information

Chemical Name:N-<(2S,4S)-4-<2-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester
CAS No.:159487-48-6
Molecular Formula:C₂₆H₃₂N₂O₆
Molecular Weight:468.55
Hs Code.:

Synonyms:N-<(2S,4S)-4-<2-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester

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Chemical Property of N-<(2S,4S)-4-<2-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester

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Technology Process of N-<(2S,4S)-4-<2-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester

There total 1 articles about N-<(2S,4S)-4-<2-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1738-68-7
Gly-OBz

: N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline benzyl ester triflate

: 159487-48-6
N-<(2S,4S)-4-<2-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester

Guidance literature:: In dichloromethane; at 0 ℃; for 20h; Yield given;
DOI:10.1021/jo00092a022

Reference yield: 78.0%

: 146432-42-0
2-[bis(benzyloxycarbonylmethyl)amino]ethyl bromide

: 159487-48-6
N-<(2S,4S)-4-<2-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester

: 159487-49-7
N-<<2-Bis<(benzyloxycarbonyl)methyl>amino>ethyl>-N-<(2S,4S)-4-<2-(benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester

Guidance literature:: With dipotassium hydrogenphosphate; In acetonitrile; at 50 ℃; for 22h;
DOI:10.1021/jo00092a022

Reference yield:

: 159487-48-6
N-<(2S,4S)-4-<2-(Benzyloxycarbonyl)-1-(tert-butoxycarbonyl)pyrrolidinyl>>glycine benzyl ester

: 159487-50-0
(2S,4S)-4-{Benzyloxycarbonylmethyl-[2-(bis-benzyloxycarbonylmethyl-amino)-ethyl]-amino}-pyrrolidine-2-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / aq. K₂HPO₄ / acetonitrile / 22 h / 50 °C

2: 99 percent / TFA / CH₂Cl₂ / 1.) 0 deg C, 10 min, 2.) r.t., 2 h

With dipotassium hydrogenphosphate; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jo00092a022