1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanone

Base Information

• Chemical Name: 1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanone
• CAS No.: 151792-81-3
• Molecular Formula: C₁₅H₁₄O₄S
• Molecular Weight: 290.34
• Mol file: 151792-81-3.mol

Synonyms:1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanone

Chemical Property of 1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanone

There total 1 articles about 1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ortho-mercaptophenol (1121-24-0) + 3-Hydroxy-4-methoxy-α-chloroacetophenone (55761-46-1) → 1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanone (151792-81-3)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1) toluene, reflux, 15 min, 2) toluene, reflux, 7 h;

Reference yield: 100.0%

1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanone (151792-81-3) → 1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanol (151792-86-8)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 0.166667h;

Reference yield:

1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanone (151792-81-3) → 2-(3-Hydroxy-4-methoxyphenyl)-2,3-dihydro-1,4-benzoxathiine S,S-dioxide

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / NaBH₄ / ethanol / 0.17 h

2: 100 percent / amberlyst 15 / toluene / 2 h / Heating

3: 36 percent / NaHCO₃, 3-chloroperbenzoic acid / CH₂Cl₂ / 5 h / Ambient temperature

With sodium tetrahydroborate; Amberlyst 15; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; toluene;

upstream raw materials:

ortho-mercaptophenol

3-Hydroxy-4-methoxy-α-chloroacetophenone

Downstream raw materials:

1-(3-Hydroxy-4-methoxyphenyl)-2-(2-hydroxyphenylthio)ethanol

2-(3-Hydroxy-4-methoxyphenyl)-2,3-dihydro-1,4-benzoxathiine