(2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane

Base Information

Chemical Name:(2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane
CAS No.:144240-01-7
Molecular Formula:C₃₁H₄₁N₅O₄
Molecular Weight:547.698
Hs Code.:

(2S,3S,4S,5S)-5-amino-2-<N-<N-<<N-methyl-N-(2-pyridinylmethyl)amino>carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane

Synonyms:(2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane

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Chemical Property of (2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane

Chemical Property:

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Technology Process of (2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane

There total 9 articles about (2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 134878-06-1
(2S,3S,4S,5S)-2,5-diamino-1,6-diphenyl-3,4-hexanediol

: 134807-31-1
N-<carbonyl>valine p-nitrophenyl ester

: 144240-01-7
(2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane

Guidance literature:: In N,N-dimethyl-formamide; at 60 ℃; for 1h;
DOI:10.1021/jm00055a003

Reference yield:

: 3731-51-9
2-(Aminomethyl)pyridine

: 144240-01-7
(2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / CH₂Cl₂ / Ambient temperature

2: 1.) sodium hydride / 1.) THF, 0 deg C, 15 min, 2.) THF, RT, 2 h

3: HCl / dioxane / 0.5 h / 40 °C

4: CH₂Cl₂ / 2.5 h / Ambient temperature

5: 0.5M aq. LiOH / dioxane / 2 h

6: EDC / tetrahydrofuran; dimethylformamide / 4 h

7: 40 percent / dimethylformamide / 1 h / 60 °C

With hydrogenchloride; lithium hydroxide; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00055a003

Reference yield:

: 30293-86-8
methyl (S)-(-)-2-isocyanato-3-methylbutyrate

: 144240-01-7
(2S,3S,4S,5S)-5-amino-2-carbonyl>valinyl>amino>-3,4-dihydroxy-1,6-diphenylhexane

Guidance literature:: Multi-step reaction with 4 steps

1: CH₂Cl₂ / 2.5 h / Ambient temperature

2: 0.5M aq. LiOH / dioxane / 2 h

3: EDC / tetrahydrofuran; dimethylformamide / 4 h

4: 40 percent / dimethylformamide / 1 h / 60 °C

With lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00055a003