N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)acrylamide

Base Information

Chemical Name:N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)acrylamide
CAS No.:1616380-86-9
Molecular Formula:C₂₇H₃₄FN₅O₃Si
Molecular Weight:523.683
Hs Code.:

Synonyms:N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)acrylamide

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Chemical Property of N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)acrylamide

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Technology Process of N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)acrylamide

There total 4 articles about N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)aniline

: 1616381-19-1
N-{3-[(2-chloro-5-fluoropyrimidin-4-yl)amino]phenyl}prop-2-enamide

: 1616380-86-9
N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)acrylamide

Guidance literature:: In butan-1-ol; at 135 ℃; for 3h;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1616380-86-9
N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / 0.5 h / 80 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

3: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere

4: butan-1-ol / 3 h / 135 °C

With 1H-imidazole; palladium on activated charcoal; hydrogen; caesium carbonate; In methanol; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 16365-27-8
2-(4-nitrophenoxy)ethanol

: 1616380-86-9
N-(3-((2-((4-(2-((tert-butyldimethylsilyl)oxy)ethoxy)phenyl)amino)-5-fluoropyrimidin-4-yl)amino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 1 h / 20 °C

2: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere

3: butan-1-ol / 3 h / 135 °C

With 1H-imidazole; palladium on activated charcoal; hydrogen; In methanol; N,N-dimethyl-formamide; butan-1-ol;