[5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine

Base Information

Chemical Name:[5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine
CAS No.:1071137-66-0
Molecular Formula:C₁₉H₁₈BrClN₄
Molecular Weight:417.736
Hs Code.:

Synonyms:[5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine

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Chemical Property of [5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine

Chemical Property:

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Technology Process of [5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine

There total 12 articles about [5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071137-22-8
[4-(1-chloro[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine

: 1071137-66-0
[5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; at -10 ℃;

Reference yield:

: 1003-73-2
3-picoline-N-oxide

: 1071137-66-0
[5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine

Guidance literature:: Multi-step reaction with 11 steps

1.1: dimethyl sulfate / 0 - 40 °C

1.2: 40 °C

2.1: sulfuric acid / dichloromethane / 8 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 2 h / -78 °C

4.1: acetic acid / 100 °C

5.1: ammonia / ethanol; water / 20 °C

6.1: tetramethlyammonium chloride; trichlorophosphate / 36 h / 110 °C

7.1: 3 h / Heating / reflux

8.1: potassium tert-butylate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 °C

9.1: potassium tert-butylate; water / tert-butyl alcohol / 100 °C

10.1: tetramethlyammonium chloride; trichlorophosphate / 110 °C

11.1: N-Bromosuccinimide / N,N-dimethyl-formamide / -10 °C

With N-Bromosuccinimide; n-butyllithium; sulfuric acid; potassium tert-butylate; ammonia; water; tetramethlyammonium chloride; acetic acid; dimethyl sulfate; trichlorophosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 7584-05-6
3-methyl-4-cyanopyridine

: 1071137-66-0
[5-bromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / dichloromethane / 8 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 2 h / -78 °C

3.1: acetic acid / 100 °C

4.1: ammonia / ethanol; water / 20 °C

5.1: tetramethlyammonium chloride; trichlorophosphate / 36 h / 110 °C

6.1: 3 h / Heating / reflux

7.1: potassium tert-butylate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 °C

8.1: potassium tert-butylate; water / tert-butyl alcohol / 100 °C

9.1: tetramethlyammonium chloride; trichlorophosphate / 110 °C

10.1: N-Bromosuccinimide / N,N-dimethyl-formamide / -10 °C

With N-Bromosuccinimide; n-butyllithium; sulfuric acid; potassium tert-butylate; ammonia; water; tetramethlyammonium chloride; acetic acid; trichlorophosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;