4-{4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-[1,2,3]triazole-1-sulfonyl}-benzoic acid

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Chemical Name:4-{4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-[1,2,3]triazole-1-sulfonyl}-benzoic acid
CAS No.:1394825-10-5
Molecular Formula:C₂₉H₁₉ClF₃N₃O₅S
Molecular Weight:614.001
Hs Code.:

Synonyms:4-{4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-[1,2,3]triazole-1-sulfonyl}-benzoic acid

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Chemical Property of 4-{4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-[1,2,3]triazole-1-sulfonyl}-benzoic acid

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Technology Process of 4-{4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-[1,2,3]triazole-1-sulfonyl}-benzoic acid

There total 2 articles about 4-{4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-[1,2,3]triazole-1-sulfonyl}-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1271725-00-8
4-[4-(4-bromo-phenyl)-[1,2,3]triazole-1-sulfonyl]-benzoic acid

: 849062-11-9
(2-((2-chloro-5-(trifluoromethyl)phenoxy)methyl)phenyl)boronic acid

: 1394825-10-5
4-{4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-[1,2,3]triazole-1-sulfonyl}-benzoic acid

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride; In tetrahydrofuran; water; at 120 ℃; under 12929 Torr; Microwave irradiation; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.05.014

Reference yield:

: 766-96-1
4-bromo-1-ethynylbenzene

: 17202-49-2
p-carboxybenzenesulfonyl azide

: 1394825-10-5
4-{4-[2'-(2-chloro-5-trifluoromethyl-phenoxymethyl)-biphenyl-4-yl]-[1,2,3]triazole-1-sulfonyl}-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine; copper(l) iodide / chloroform / 12 h / 0 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Microwave irradiation; Inert atmosphere

With 2,6-dimethylpyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; cesium fluoride; In tetrahydrofuran; chloroform; water; 2: Suzuki coupling;
DOI:10.1016/j.ejmech.2012.05.014