acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-ethylamino)-ethylcarbamoyl]-vinyl}-phenyl ester

Base Information

• Chemical Name: acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-ethylamino)-ethylcarbamoyl]-vinyl}-phenyl ester
• CAS No.: 556065-69-1
• Molecular Formula: C₂₀H₂₉N₃O₅
• Molecular Weight: 391.467
• Mol file: 556065-69-1.mol

Synonyms:acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-ethylamino)-ethylcarbamoyl]-vinyl}-phenyl ester

Chemical Property of acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-ethylamino)-ethylcarbamoyl]-vinyl}-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-ethylamino)-ethylcarbamoyl]-vinyl}-phenyl ester

There total 3 articles about acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-ethylamino)-ethylcarbamoyl]-vinyl}-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

p-acetoxycinnamoyl chloride (53901-95-4,108608-06-6,58523-18-5) + [2-(2-amino-ethylamino)-ethyl]-carbamic acid tert-butyl ester (193206-49-4) → acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-ethylamino)-ethylcarbamoyl]-vinyl}-phenyl ester (556065-69-1) + Acetic acid 4-{(E)-2-[{2-[(E)-3-(4-acetoxy-phenyl)-acryloylamino]-ethyl}-(2-tert-butoxycarbonylamino-ethyl)-carbamoyl]-vinyl}-phenyl ester (660426-60-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1016/S0031-9422(03)00133-X

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-ethylamino)-ethylcarbamoyl]-vinyl}-phenyl ester (556065-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 16 percent / Et₃N / CH₂Cl₂ / 20 °C

With triethylamine; In dichloromethane;

DOI:10.1016/S0031-9422(03)00133-X

Reference yield:

4-acetoxycinnamic acid (27542-85-4) → acetic acid 4-{2-[2-(2-tert-butoxycarbonylamino-ethylamino)-ethylcarbamoyl]-vinyl}-phenyl ester (556065-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2; DMF / CH₂Cl₂ / 1 h / Heating

2: 16 percent / Et₃N / CH₂Cl₂ / 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1016/S0031-9422(03)00133-X

upstream raw materials:

p-acetoxycinnamoyl chloride

[2-(2-amino-ethylamino)-ethyl]-carbamic acid tert-butyl ester

di-tert-butyl dicarbonate

4-acetoxycinnamic acid