4-(3-fluoro-4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Base Information

Chemical Name:4-(3-fluoro-4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
CAS No.:1290546-50-7
Molecular Formula:C₂₁H₁₅F₅N₄O₃
Molecular Weight:466.367
Hs Code.:

Synonyms:4-(3-fluoro-4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

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Chemical Property of 4-(3-fluoro-4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

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Technology Process of 4-(3-fluoro-4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

There total 4 articles about 4-(3-fluoro-4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 757251-39-1
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

: 69922-27-6
1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene

: 1290546-50-7
4-(3-fluoro-4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Guidance literature:: In dichloromethane; for 18h;

Reference yield:

: 5470-22-4
4-chloropicolinic acid

: 1290546-50-7
4-(3-fluoro-4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / tetrahydrofuran / 15.5 h / 0 - 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 3.03 h / Inert atmosphere

3.2: 10 h / 90 °C / Inert atmosphere

4.1: dichloromethane / 18 h

With oxalyl dichloride; potassium tert-butylate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 51727-15-2
4-chloro-2-pyridine carboxylic acid chloride hydrochloride

: 1290546-50-7
4-(3-fluoro-4-(3-(2-fluoro-5-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran / 16.42 h / 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide / 3.03 h / Inert atmosphere

2.2: 10 h / 90 °C / Inert atmosphere

3.1: dichloromethane / 18 h

With potassium tert-butylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;