(S)-N₁-[7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine

Base Information

• Chemical Name: (S)-N₁-[7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine
• CAS No.: 1438883-32-9
• Molecular Formula: C₂₀H₁₇BrFN₅S
• Molecular Weight: 458.357

Synonyms:(S)-N₁-[7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine

Chemical Property of (S)-N₁-[7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine

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Technology Process of (S)-N₁-[7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine

There total 6 articles about (S)-N₁-[7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H25BrFN5O2S (1438887-55-8) → (S)-N1-[7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine (1438883-32-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃;

Reference yield:

3-fluoropyridine-4-carbaldehyde (40273-47-0) → (S)-N1-[7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine (1438883-32-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol / 0.33 h / 140 °C / Microwave irradiation

1.2: 18 h / 20 °C

2.1: acetic acid; bromine / 18 h / 20 - 80 °C

3.1: triethylamine; dmap / dichloromethane / 4 h / 20 °C

4.1: 18 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; dmap; bromine; acetic acid; triethylamine; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

C26H27BrFN3O3S2 (1438887-74-1) → (S)-N1-[7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-yl]-3-phenylpropane-1,2-diamine (1438883-32-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 18 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 20 °C

With hydrogenchloride; In 1,4-dioxane;

upstream raw materials:

2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-ol

3-aminothiophene-2-carboxamide

3-fluoropyridine-4-carbaldehyde

7-bromo-2-(3-fluoropyridin-4-yl)thieno[3,2-d]pyrimidin-4-ol

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