9-[1-(4-methoxyphenyl)-4-hydroxy-piperidin-4-yl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

Base Information

Chemical Name:9-[1-(4-methoxyphenyl)-4-hydroxy-piperidin-4-yl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid
CAS No.:267428-49-9
Molecular Formula:C₂₄H₃₅NO₆
Molecular Weight:433.545
Hs Code.:

Synonyms:9-[1-(4-methoxyphenyl)-4-hydroxy-piperidin-4-yl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-[1-(4-methoxyphenyl)-4-hydroxy-piperidin-4-yl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 9-[1-(4-methoxyphenyl)-4-hydroxy-piperidin-4-yl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

There total 1 articles about 9-[1-(4-methoxyphenyl)-4-hydroxy-piperidin-4-yl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 169822-66-6
3,3-Dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

: 267428-49-9
9-[1-(4-methoxyphenyl)-4-hydroxy-piperidin-4-yl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

Guidance literature:: 3,3-Dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at 50 ℃; for 2h; Further stages.;
DOI:10.1021/ja983716r

Reference yield: 84.0%

: 267428-49-9
9-[1-(4-methoxyphenyl)-4-hydroxy-piperidin-4-yl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

: 267428-50-2
9-[1-(4-methoxyphenylpiperidin)-4-ylidene]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane

Guidance literature:: With N,N-dimethylformamide dineopentyl acetal; In acetonitrile; Heating;
DOI:10.1021/ja983716r

Reference yield:

: 267428-49-9
9-[1-(4-methoxyphenyl)-4-hydroxy-piperidin-4-yl]-3,3-dimethyl-1,5-dioxaspiro[5.5]undecane-9-carboxylic acid

: 267428-52-4
4-[1-(4-methoxyphenyl)piperidin-4-yl]cyclohexanone

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / N,N-dimethylformamide dineopentyl acetal / acetonitrile / Heating

2: 86 percent / acetic acid; H₂ / PtO₂ / ethyl acetate / 2068.65 Torr

3: 89 percent / hydrochloric acid; H₂O / tetrahydrofuran / 1.5 h / Heating

With hydrogenchloride; water; hydrogen; acetic acid; N,N-dimethylformamide dineopentyl acetal; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate; acetonitrile; 1: Decarboxylation / 2: Hydrogenation / 3: Carbonylation;
DOI:10.1021/ja983716r