2-Amino-6-[(2-{[2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl]amino}ethyl)amino]pyridine-3-carbonitrile

Base Information

• Chemical Name: 2-Amino-6-[(2-{[2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl]amino}ethyl)amino]pyridine-3-carbonitrile
• CAS No.: 1196678-12-2
• Molecular Formula: C₂₇H₂₈Cl₂N₁₀
• Molecular Weight: 563.492
• Mol file: 1196678-12-2.mol

Synonyms:2-Amino-6-[(2-{[2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl]amino}ethyl)amino]pyridine-3-carbonitrile

Chemical Property of 2-Amino-6-[(2-{[2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl]amino}ethyl)amino]pyridine-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Amino-6-[(2-{[2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl]amino}ethyl)amino]pyridine-3-carbonitrile

There total 11 articles about 2-Amino-6-[(2-{[2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl]amino}ethyl)amino]pyridine-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-amino-6-[(2-aminoethyl)amino]pyridine-3-carbonitrile dihydrochloride + 5-Chloro-2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]pyrimidine (1196678-36-0) → 2-Amino-6-[(2-{[2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl]amino}ethyl)amino]pyridine-3-carbonitrile (1196678-12-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 130 ℃; for 0.5h; Microwave irradiation;

Reference yield:

tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate (187834-88-4) → 2-Amino-6-[(2-{[2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl]amino}ethyl)amino]pyridine-3-carbonitrile (1196678-12-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1-methyl-pyrrolidin-2-one / 3 h / 150 °C

2.1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C

3.1: sodium cyanoborohydride; acetic acid / methanol / Reflux; Molecular sieve

4.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 2.5 h / 120 °C

4.2: pH 7

5.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 130 °C / Microwave irradiation

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dimethyl sulfoxide;

Reference yield:

2-amino-6-chloro-3-cyanopyridine (52471-07-5) → 2-Amino-6-[(2-{[2-(1-cyclopropylpiperidin-4-yl)-7-(2,4-dichlorophenyl)[1,2,4]triazolo[1,5-c]-pyrimidin-5-yl]amino}ethyl)amino]pyridine-3-carbonitrile (1196678-12-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 1.5 h / 115 °C / Microwave irradiation

2: hydrogenchloride / 1,4-dioxane / 0.5 h

3: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 130 °C / Microwave irradiation

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dimethyl sulfoxide;

upstream raw materials:

tert-butyl 4-(hydrazinecarbonyl)piperidine-1-carboxylate

2-amino-6-chloro-3-cyanopyridine

2,4-dichlorobenzylnitrile

tert-butyl {2-[(6-amino-5-cyanopyridin-2-yl)amino]ethyl}carbamate