isopropyl 4-amino-2,5-anhydro-3-O-tert-butyldiphenylsilyl-4-N-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonyl)-4-deoxy-L-ribonate

Base Information

Chemical Name:isopropyl 4-amino-2,5-anhydro-3-O-tert-butyldiphenylsilyl-4-N-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonyl)-4-deoxy-L-ribonate
CAS No.:857499-51-5
Molecular Formula:C₄₅H₅₆N₄O₇Si₂
Molecular Weight:821.133
Hs Code.:

isopropyl 4-amino-2,5-anhydro-3-O-tert-butyldiphenylsilyl-4-N-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonyl)-4-deoxy-L-ribonate

Synonyms:isopropyl 4-amino-2,5-anhydro-3-O-tert-butyldiphenylsilyl-4-N-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonyl)-4-deoxy-L-ribonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of isopropyl 4-amino-2,5-anhydro-3-O-tert-butyldiphenylsilyl-4-N-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonyl)-4-deoxy-L-ribonate

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Technology Process of isopropyl 4-amino-2,5-anhydro-3-O-tert-butyldiphenylsilyl-4-N-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonyl)-4-deoxy-L-ribonate

There total 2 articles about isopropyl 4-amino-2,5-anhydro-3-O-tert-butyldiphenylsilyl-4-N-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonyl)-4-deoxy-L-ribonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 605668-26-6
isopropyl 2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonate

: 857499-51-5
isopropyl 4-amino-2,5-anhydro-3-O-tert-butyldiphenylsilyl-4-N-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonyl)-4-deoxy-L-ribonate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / propan-2-ol / 13 h / 20 °C

2: 0.58 g / DIPEA; TBTU / dimethylformamide / 23 h / 20 °C

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.tet.2006.05.067

Reference yield:

: 909723-62-2
(2S,3S,4R)-4-Amino-3-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-carboxylic acid isopropyl ester

: 909723-63-3
(2S,3S,4R)-4-Azido-3-(tert-butyl-diphenyl-silanyloxy)-tetrahydro-furan-2-carboxylic acid

: 857499-51-5
isopropyl 4-amino-2,5-anhydro-3-O-tert-butyldiphenylsilyl-4-N-(2,5-anhydro-4-azido-3-O-tert-butyldiphenylsilyl-4-deoxy-L-ribonyl)-4-deoxy-L-ribonate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 23h;
DOI:10.1016/j.tet.2006.05.067