2-acetyl-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one

Base Information

• Chemical Name: 2-acetyl-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one
• CAS No.: 944478-15-3
• Molecular Formula: C₁₈H₁₅N₅O₅
• Molecular Weight: 381.348
• Mol file: 944478-15-3.mol

Synonyms:2-acetyl-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one

Chemical Property of 2-acetyl-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetyl-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one

There total 1 articles about 2-acetyl-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

6-amino-2,4-dihydro-4-(4-nitrophenyl)-3-methylpyrano[2,3-c]pyrazole-5-carbonitrile (89607-34-1,879451-69-1) + acetic anhydride (108-24-7) → 2-acetyl-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one (944478-15-3)

Guidance literature:

for 3h; Heating;

DOI:10.1002/ardp.200700005

Reference yield: 89.0%

2-acetyl-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one (944478-15-3) → 3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one (944478-16-4)

Guidance literature:

With ammonium hydroxide; In ethanol; at 20 ℃; for 3h;

DOI:10.1002/ardp.200700005

Reference yield:

2-acetyl-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one (944478-15-3) → 5-(2-methoxyethylsulfanyl)-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine

Guidance literature:

Multi-step reaction with 4 steps

1.1: 89 percent / aq. NH₄OH / ethanol / 3 h / 20 °C

2.1: 85 percent / POCl₃ / 2 h / Heating

3.1: 77 percent / thiourea / ethanol / 4 h / Heating

4.1: NaH / dimethylformamide / 1 h / 70 °C

4.2: 72 percent / dimethylformamide / 8 h / 90 °C

With ammonium hydroxide; sodium hydride; thiourea; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/ardp.200700005

upstream raw materials:

6-amino-2,4-dihydro-4-(4-nitrophenyl)-3-methylpyrano[2,3-c]pyrazole-5-carbonitrile

acetic anhydride

Downstream raw materials:

3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5(6H)-one

3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidin-5-ylhydrazine

5-chloro-3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine

3,7-dimethyl-4-(4-nitrophenyl)-2,4-dihydropyrazolo[4',3':5,6]pyrano[2,3-d]pyrimidine-5(6H)-thione