4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid

Base Information

Chemical Name:4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid
CAS No.:185540-67-4
Molecular Formula:C₁₆H₁₅NO₅S
Molecular Weight:333.365
Hs Code.:

Synonyms:4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid

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Chemical Property of 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid

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Technology Process of 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid

There total 5 articles about 4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 185540-66-3
4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid methyl ester

: 185540-67-4
4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 5h; Ambient temperature;
DOI:10.1021/jm9605288

Reference yield:

: 713-52-0
methyl 3-hydroxy-4-nitrobenzoate

: 185540-67-4
4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 56 percent / K₂CO₃ / dimethylformamide / 2 h / 100 °C

2: 83 percent / Zn, acetic acid / 2 h / Ambient temperature

3: 40 percent / pyridine / Ambient temperature

4: 71 percent / NaH / dimethylformamide / 1 h / 0 °C

5: 89 percent / 1N aq. NaOH / ethanol / 5 h / Ambient temperature

With pyridine; sodium hydroxide; sodium hydride; potassium carbonate; acetic acid; zinc; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9605288

Reference yield:

: 185540-64-1
4-Amino-3-(2-bromo-ethoxy)-benzoic acid methyl ester

: 185540-67-4
4-(Toluene-4-sulfonyl)-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / pyridine / Ambient temperature

2: 71 percent / NaH / dimethylformamide / 1 h / 0 °C

3: 89 percent / 1N aq. NaOH / ethanol / 5 h / Ambient temperature

With pyridine; sodium hydroxide; sodium hydride; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm9605288