N-((3R,4R,4aR,5R,6R,8aS)-5,6-Dihydroxy-3-methyl-8-methylene-1-oxo-octahydro-isochromen-4-yl)-C-p-tolyl-methanesulfonamide

Base Information

Chemical Name:N-((3R,4R,4aR,5R,6R,8aS)-5,6-Dihydroxy-3-methyl-8-methylene-1-oxo-octahydro-isochromen-4-yl)-C-p-tolyl-methanesulfonamide
CAS No.:88549-91-1
Molecular Formula:C₁₉H₂₅NO₆S
Molecular Weight:395.477
Hs Code.:

Synonyms:N-((3R,4R,4aR,5R,6R,8aS)-5,6-Dihydroxy-3-methyl-8-methylene-1-oxo-octahydro-isochromen-4-yl)-C-p-tolyl-methanesulfonamide

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Chemical Property of N-((3R,4R,4aR,5R,6R,8aS)-5,6-Dihydroxy-3-methyl-8-methylene-1-oxo-octahydro-isochromen-4-yl)-C-p-tolyl-methanesulfonamide

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Technology Process of N-((3R,4R,4aR,5R,6R,8aS)-5,6-Dihydroxy-3-methyl-8-methylene-1-oxo-octahydro-isochromen-4-yl)-C-p-tolyl-methanesulfonamide

There total 21 articles about N-((3R,4R,4aR,5R,6R,8aS)-5,6-Dihydroxy-3-methyl-8-methylene-1-oxo-octahydro-isochromen-4-yl)-C-p-tolyl-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₃₁NO₇SSe

: 88549-91-1
N-((3R,4R,4aR,5R,6R,8aS)-5,6-Dihydroxy-3-methyl-8-methylene-1-oxo-octahydro-isochromen-4-yl)-C-p-tolyl-methanesulfonamide

Guidance literature:: With pyridine; In ethyl acetate; Yield given;

Reference yield:

: 88549-85-3
(1aS,3R,3aR,6R,6aR,6bR)-6-((R)-1-Hydroxy-ethyl)-4-oxo-octahydro-1-oxa-5-aza-cyclopropa[e]indene-3-carboxylic acid methyl ester

: 88549-91-1
N-((3R,4R,4aR,5R,6R,8aS)-5,6-Dihydroxy-3-methyl-8-methylene-1-oxo-octahydro-isochromen-4-yl)-C-p-tolyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 12 steps

1: H₂O / 2 h / 50 - 60 °C

2: Et₃N / methanol

3: p-toluenesulfonic acid / tetrahydrofuran

4: p-toluenesulfonic acid / CH₂Cl₂

5: LiAlH₄ / tetrahydrofuran

6: Et₃N / CH₂Cl₂

7: 96 percent / NaBH₄ / ethanol

8: n-BuLi / -78 °C

9: p-toluenesulfonic acid / methanol

10: 86 percent / NaOMe / methanol / 1 h / Heating

11: O₃ / CH₂Cl₂; methanol / -78 °C

12: pyridine / ethyl acetate

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; sodium methylate; toluene-4-sulfonic acid; ozone; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: (1R,3aR,4R,6R,7R,7aR)-6,7-Dihydroxy-1-((R)-1-hydroxy-ethyl)-3-oxo-octahydro-isoindole-4-carboxylic acid methyl ester

: 88549-91-1
N-((3R,4R,4aR,5R,6R,8aS)-5,6-Dihydroxy-3-methyl-8-methylene-1-oxo-octahydro-isochromen-4-yl)-C-p-tolyl-methanesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1: p-toluenesulfonic acid / tetrahydrofuran

2: p-toluenesulfonic acid / CH₂Cl₂

3: LiAlH₄ / tetrahydrofuran

4: Et₃N / CH₂Cl₂

5: 96 percent / NaBH₄ / ethanol

6: n-BuLi / -78 °C

7: p-toluenesulfonic acid / methanol

8: 86 percent / NaOMe / methanol / 1 h / Heating

9: O₃ / CH₂Cl₂; methanol / -78 °C

10: pyridine / ethyl acetate

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; n-butyllithium; sodium methylate; toluene-4-sulfonic acid; ozone; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate;