1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione

Base Information

Chemical Name:1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione
CAS No.:1448522-90-4
Molecular Formula:C₂₅H₂₀N₂O₂
Molecular Weight:380.446
Hs Code.:

Synonyms:1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione

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Chemical Property of 1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione

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Technology Process of 1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione

There total 4 articles about 1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1448522-88-0
1-benzyl-3-(2-(7-chloroindolin-1-yl)-2-oxoethyl)indolin-2-one

: 1448522-90-4
1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione

: 1448522-91-5
(E)-1-(1-benzyl-2-oxoindolin-3-ylidene)-4,5-dihydropyrrolo[3,2,1-hi]indol-2(1H)-one

Guidance literature:: With (Ra)-(2'-methoxy-[1,1']-binaphthalenyl-2-yl)-diphenylphosphine; palladium diacetate; caesium carbonate; In toluene; at 100 ℃; for 16h; Reagent/catalyst; Inert atmosphere;
DOI:10.1002/chem.201203150

Reference yield:

: 2-(1-benzyl-2-oxoindolin-3-ylidene)acetic acid

: 1448522-90-4
1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione

: 1448522-91-5
(E)-1-(1-benzyl-2-oxoindolin-3-ylidene)-4,5-dihydropyrrolo[3,2,1-hi]indol-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 5%-palladium/activated carbon; hydrogen / methanol / 16 h / 20 °C / Inert atmosphere

2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 0.25 h / 20 °C / Inert atmosphere

3: dichloromethane / 2 h / 20 °C / Inert atmosphere

4: (Ra)-(2'-methoxy-[1,1']-binaphthalenyl-2-yl)-diphenylphosphine; caesium carbonate; palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

With (Ra)-(2'-methoxy-[1,1']-binaphthalenyl-2-yl)-diphenylphosphine; oxalyl dichloride; 5%-palladium/activated carbon; hydrogen; palladium diacetate; caesium carbonate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.201203150

Reference yield:

: C₁₇H₁₄ClNO₂

: 1448522-90-4
1-benzyl-1',2'-dihydrospiro[indoline-3,6'-pyrrolo[3,2,1-ij]quinoline]-2,4'(5'H)-dione

: 1448522-91-5
(E)-1-(1-benzyl-2-oxoindolin-3-ylidene)-4,5-dihydropyrrolo[3,2,1-hi]indol-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 2 h / 20 °C / Inert atmosphere

2: (Ra)-(2'-methoxy-[1,1']-binaphthalenyl-2-yl)-diphenylphosphine; caesium carbonate; palladium diacetate / toluene / 16 h / 100 °C / Inert atmosphere

With (Ra)-(2'-methoxy-[1,1']-binaphthalenyl-2-yl)-diphenylphosphine; palladium diacetate; caesium carbonate; In dichloromethane; toluene;
DOI:10.1002/chem.201203150