N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valine methyl ester

Base Information

Chemical Name:N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valine methyl ester
CAS No.:166169-40-0
Molecular Formula:C₃₃H₄₂N₂O₄S
Molecular Weight:562.773
Hs Code.:

Synonyms:N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valine methyl ester

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Chemical Property of N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valine methyl ester

Chemical Property:

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Technology Process of N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valine methyl ester

There total 1 articles about N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6306-52-1
L-valine methylester hydrochloride

: 149910-63-4
N-α-(tert-butoxycarbonyl)-S-(triphenylmethyl)-L-cysteinal

: 166169-40-0
N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valine methyl ester

Guidance literature:: With sodium cyanoborohydride; acetic acid; Yield given. Multistep reaction; 1.) MeOH, RT, 30 min, 2.) MeOH, THF, RT, 2 h;
DOI:10.1021/jm950642a

Reference yield: 92.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 166169-40-0
N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valine methyl ester

: 166169-41-1
(R*)-N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-N-(benzyloxycarbonyl)-L-valine methyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1021/jm950642a

Reference yield:

: 166169-40-0
N-<<2-<<(1,1-dimethylethoxy)carbonyl>amino>-3-<(triphenylmethyl)thio>propyl>carbonyl>-L-valine methyl ester

: (S)-2-[((S)-2-{(S)-2-[Benzyloxycarbonyl-((R)-2-tert-butoxycarbonylamino-3-tritylsulfanyl-propyl)-amino]-3-methyl-butyryl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-succinamic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / diisopropylethylamine / CH₂Cl₂ / 16 h / 0 - 20 °C

2: 100 percent / 2 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature

3: 72 percent / N,N-diisopropylethylamine, Bop-Cl / CH₂Cl₂ / 16 h / 0 °C

4: 100 percent / 1 N LiOH / tetrahydrofuran; methanol / 16 h / Ambient temperature

5: N,N-diisopropylethylamine, Bop / acetonitrile; dimethylformamide / 16 h

6: 2 N LiOH / tetrahydrofuran / 4 h / Ambient temperature

With lithium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm950642a