N-(2-chloro-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Base Information

Chemical Name:N-(2-chloro-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide
CAS No.:1609565-30-1
Molecular Formula:C₂₂H₁₉ClFN₅O₂SSi
Molecular Weight:500.028
Hs Code.:

Synonyms:N-(2-chloro-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

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Chemical Property of N-(2-chloro-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

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Technology Process of N-(2-chloro-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

There total 3 articles about N-(2-chloro-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.5%

: 1609565-18-5
6-bromo-3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazine

: 1609565-31-2
(6-chloro-5-((4-fluorobenzene)sulfonamide)pyridin-3-yl)boronic acid

: 1609565-30-1
N-(2-chloro-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 90 ℃; for 1h;

Reference yield:

: 1609565-17-4
6-bromo-3-iodoimidazo[1,2-b]pyridazine

: 1609565-30-1
N-(2-chloro-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / 90 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 1 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water;

Reference yield:

: 1159977-65-7
6-bromoimidazo[1,2-b]pyridazine

: 1609565-30-1
N-(2-chloro-5-(3-((trimethylsilyl)ethynyl)imidazo[1,2-b]pyridazin-6-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / methanol / 18.5 h / -10 - 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 6 h / 90 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 1 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; N-iodo-succinimide; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; water;