Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)-4-nitrophenyl)-2-methyl-5-oxo-, methyl ester

Base Information

• Chemical Name: Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)-4-nitrophenyl)-2-methyl-5-oxo-, methyl ester
• CAS No.: 124733-04-6
• Molecular Formula: C₁₇H₁₄F₂N₂O₇
• Molecular Weight: 396.304
• DSSTox Substance ID: DTXSID40924918
• Mol file: 124733-04-6.mol

Synonyms:BRN 4278113;124733-04-6;Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)-4-nitrophenyl)-2-methyl-5-oxo-, methyl ester;Furo(3,4-b)pyridine-3-carboxylic acid, 4-(2-(difluoromethoxy)-4-nitrophenyl)-1,4,5,7-tetrahydro-2-methyl-5-oxo-, methyl ester;DTXSID40924918;C17H14F2N2O7;C17-H14-F2-N2-O7;LS-70886;Methyl 4-[2-(difluoromethoxy)-4-nitrophenyl]-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate

Chemical Property of Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)-4-nitrophenyl)-2-methyl-5-oxo-, methyl ester

Chemical Property:

• Vapor Pressure: 1.22E-13mmHg at 25°C
• Boiling Point: 584.4°Cat760mmHg
• Flash Point: 307.2°C
• Density: 1.51g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 5
• Exact Mass: 396.07690711
• Heavy Atom Count: 28
• Complexity: 759

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(C2=C(N1)COC2=O)C3=C(C=C(C=C3)[N+](=O)[O-])OC(F)F)C(=O)OC

Technology Process of Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)-4-nitrophenyl)-2-methyl-5-oxo-, methyl ester

There total 1 articles about Furo(3,4-b)pyridine-3-carboxylic acid, 1,4,5,7-tetrahydro-4-(2-(difluoromethoxy)-4-nitrophenyl)-2-methyl-5-oxo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

4-(2-Difluoromethoxy-4-nitro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester (111169-84-7) → 4-(2-Difluoromethoxy-4-nitro-phenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydro-furo[3,4-b]pyridine-3-carboxylic acid methyl ester (124733-04-6)

Guidance literature:

With N-Bromosuccinimide; In chloroform; for 0.5h; Heating;

DOI:10.1007/BF00764614

upstream raw materials:

4-(2-Difluoromethoxy-4-nitro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester