1-acetyl-piperidine-4-carboxylic acid {4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenyl}-amide

Base Information

Chemical Name:1-acetyl-piperidine-4-carboxylic acid {4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenyl}-amide
CAS No.:1350444-86-8
Molecular Formula:C₂₄H₃₅N₃O₂
Molecular Weight:397.561
Hs Code.:

Synonyms:1-acetyl-piperidine-4-carboxylic acid {4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenyl}-amide

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Chemical Property of 1-acetyl-piperidine-4-carboxylic acid {4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenyl}-amide

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Technology Process of 1-acetyl-piperidine-4-carboxylic acid {4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenyl}-amide

There total 7 articles about 1-acetyl-piperidine-4-carboxylic acid {4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1-acetyl-piperidine-4-carboxylic acid chloride

: 1350445-14-5
4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)-cyclopentyl]-phenylamine

: 1350444-86-8
1-acetyl-piperidine-4-carboxylic acid {4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenyl}-amide

Guidance literature:: With pyridine; In 1,2-dichloro-ethane; at 20 ℃; for 2h;

Reference yield:

: 930-30-3
cyclopent-2-enone

: 1350444-86-8
1-acetyl-piperidine-4-carboxylic acid {4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine; acetylacetonatobis-(ethylene)rhodium(I) / 1,4-dioxane; water / 0.67 h / 20 - 105 °C / Inert atmosphere

2: ethanol; sodium tetrahydroborate / ethyl acetate

3: triethylamine / dichloromethane / 1 h / Inert atmosphere; Cooling with ice

4: potassium carbonate / acetonitrile / 16 h / 80 °C / Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere

6: pyridine / 1,2-dichloro-ethane / 2 h / 20 °C

With pyridine; sodium tetrahydroborate; ethanol; hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; acetylacetonatobis-(ethylene)rhodium(I); (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 192804-36-7
(4-(((benzyloxy)carbonyl)amino)phenyl)boronic acid

: 1350444-86-8
1-acetyl-piperidine-4-carboxylic acid {4-[(S)-3-((S)-2-methyl-pyrrolidin-1-yl)cyclopentyl]-phenyl}-amide

Guidance literature:: Multi-step reaction with 6 steps

1: (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine; acetylacetonatobis-(ethylene)rhodium(I) / 1,4-dioxane; water / 0.67 h / 20 - 105 °C / Inert atmosphere

2: ethanol; sodium tetrahydroborate / ethyl acetate

3: triethylamine / dichloromethane / 1 h / Inert atmosphere; Cooling with ice

4: potassium carbonate / acetonitrile / 16 h / 80 °C / Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C / Inert atmosphere

6: pyridine / 1,2-dichloro-ethane / 2 h / 20 °C

With pyridine; sodium tetrahydroborate; ethanol; hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; acetylacetonatobis-(ethylene)rhodium(I); (+)-2,2'-O,O-(1,1'-binaphthyl)-dioxo-N,N-diethylphospholidine; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;