5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde

Base Information

• Chemical Name: 5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde
• CAS No.: 914935-70-9
• Molecular Formula: C₁₃H₁₄BrF₂NO₂
• Molecular Weight: 334.16
• Mol file: 914935-70-9.mol

Synonyms:5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde

Chemical Property of 5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde

There total 2 articles about 5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

5-bromo-2,3,4-trifluorobenzaldehyde (914935-69-6) + cis-2,6-dimethylmorpholine (141-91-3,6485-45-6,6485-55-8) → 5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde (914935-70-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 5h; Reflux;

DOI:10.1039/c6cc03600g

Reference yield: 62.0%

cis-2,6-dimethylmorpholine + 5-bromo-2,3,4-trifluorobenzaldehyde (914935-69-6) → 5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde (914935-70-9)

Guidance literature:

With triethylamine; In acetonitrile; at 80 ℃; for 12h;

Reference yield: 85.0%

nitroacetic acid ethyl ester (626-35-7) + 5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde (914935-70-9) → C17H19BrF2N2O5

Guidance literature:

nitroacetic acid ethyl ester; 5-bromo-2-((2S,6R)-2,6-dimethylmorpholino)-3,4-difluorobenzaldehyde; With titanium tetrachloride; In tetrahydrofuran; dichloromethane-d2; at 0 ℃; for 0.0833333h;

With 4-methyl-morpholine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 12h;

DOI:10.1039/c6cc03600g

upstream raw materials:

5-bromo-2,3,4-trifluorobenzaldehyde

cis-2,6-dimethylmorpholine

Downstream raw materials:

2-((2R,6S)-2,6-dimethylmorpholino)-3,4-difluoro-5-((trimethylsilyl)ethynyl)benzaldehyde