(3-amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

Base Information

Chemical Name:(3-amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone
CAS No.:1309430-94-1
Molecular Formula:C₁₃H₈F₂N₄O₂
Molecular Weight:290.229
Hs Code.:

Synonyms:(3-amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

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Chemical Property of (3-amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

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Technology Process of (3-amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

There total 4 articles about (3-amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1309430-93-0
{2,4-difluoro-3-[hydroxy-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methyl]-phenyl}-carbamic acid methyl ester

: 1309430-94-1
(3-amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

Guidance literature:: {2,4-difluoro-3-[hydroxy-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methyl]-phenyl}-carbamic acid methyl ester; With Dess-Martin periodane; In tetrahydrofuran; at 20 ℃; for 3h;

With sodium hydrogencarbonate; sodium thiosulfate; In tetrahydrofuran; water;

Reference yield:

: 367-25-9,76563-56-9
2,4-difluorophenylamine

: 1309430-94-1
(3-amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 1.5 h / 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 20 °C

3.1: potassium hydroxide / 48 h / 50 °C

4.1: Dess-Martin periodane / tetrahydrofuran / 3 h / 20 °C

With pyridine; n-butyllithium; Dess-Martin periodane; potassium hydroxide; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 112434-18-1
benzyl 2,4-difluorophenylcarbamate

: 1309430-94-1
(3-amino-2,6-difluoro-phenyl)-(4-hydroxy-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

1.2: 20 °C

2.1: potassium hydroxide / 48 h / 50 °C

3.1: Dess-Martin periodane / tetrahydrofuran / 3 h / 20 °C

With n-butyllithium; Dess-Martin periodane; potassium hydroxide; In tetrahydrofuran; hexane;