tert-butyl benzyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate

Base Information

Chemical Name:tert-butyl benzyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate
CAS No.:1396515-13-1
Molecular Formula:C₁₉H₃₀BNO₄
Molecular Weight:347.262
Hs Code.:

Synonyms:tert-butyl benzyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl benzyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate

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Technology Process of tert-butyl benzyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate

There total 1 articles about tert-butyl benzyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 70557-99-2
2-(iodomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 42116-44-9
N-tert-butoxycarbonylbenzylamine

: 1396515-13-1
tert-butyl benzyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate

Guidance literature:: N-tert-butoxycarbonylbenzylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.166667h;

2-(iodomethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; In tetrahydrofuran; hexane; at 20 ℃;
DOI:10.1021/ol301955s

Reference yield: 74.0%

: 1396515-13-1
tert-butyl benzyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate

: 1397275-21-6
potassium tert-butyl benzyl{(trifluoroborato)methyl}carbamate

Guidance literature:: With potassium hydrogen difluoride; In water; acetone; at 0 - 20 ℃; for 0.5h;
DOI:10.1021/ol301955s

Reference yield:

: 1396515-13-1
tert-butyl benzyl{(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl}carbamate

: 1396518-13-0
tert-butyl benzyl(4-methoxybenzyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogen difluoride / acetone; water / 0.5 h / 0 - 20 °C

2: chloro (2-dicyclohexylphosphino-2 ‘,4’,6’-triisopropyl-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II); caesium carbonate / water; toluene / 3 h / 85 °C / Inert atmosphere

With potassium hydrogen difluoride; chloro (2-dicyclohexylphosphino-2 ‘,4’,6’-triisopropyl-1,1’-biphenyl)[2-(2’-amino-1,1‘-biphenyl)]palladium(II); caesium carbonate; In water; acetone; toluene; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol301955s