Technology Process of ((R)-8-Benzyloxy-nonyloxy)-tert-butyl-dimethyl-silane
There total 7 articles about ((R)-8-Benzyloxy-nonyloxy)-tert-butyl-dimethyl-silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 48 percent / Et3N, DMAP / CH2Cl2 / 6 h
2: 84 percent / PCC, NaOAc / CH2Cl2 / 3 h
3: 89 percent / diethyl ether / 3 h / 0 °C
4: porcine pancreatic lipase / diisopropyl ether / 18 h
5: 97 percent / 2N alcoholic KOH / 12 h / Ambient temperature
6: 1.) NaH / 1.) THF, 60 deg C, 1 h, 2.) THF, RT, overnight
With
dmap; potassium hydroxide; porcine pancreatic lipase; sodium acetate; sodium hydride; triethylamine; pyridinium chlorochromate;
In
diethyl ether; dichloromethane; di-isopropyl ether;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89 percent / diethyl ether / 3 h / 0 °C
2: porcine pancreatic lipase / diisopropyl ether / 18 h
3: 97 percent / 2N alcoholic KOH / 12 h / Ambient temperature
4: 1.) NaH / 1.) THF, 60 deg C, 1 h, 2.) THF, RT, overnight
With
potassium hydroxide; porcine pancreatic lipase; sodium hydride;
In
diethyl ether; di-isopropyl ether;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 84 percent / PCC, NaOAc / CH2Cl2 / 3 h
2: 89 percent / diethyl ether / 3 h / 0 °C
3: porcine pancreatic lipase / diisopropyl ether / 18 h
4: 97 percent / 2N alcoholic KOH / 12 h / Ambient temperature
5: 1.) NaH / 1.) THF, 60 deg C, 1 h, 2.) THF, RT, overnight
With
potassium hydroxide; porcine pancreatic lipase; sodium acetate; sodium hydride; pyridinium chlorochromate;
In
diethyl ether; dichloromethane; di-isopropyl ether;
