(1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate

Base Information

Chemical Name:(1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate
CAS No.:1265177-86-3
Molecular Formula:C₃₈H₆₁NO₇Si₂
Molecular Weight:700.076
Hs Code.:

(1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate

Synonyms:(1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate

Suppliers and Price of (1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate

There total 22 articles about (1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1265177-85-2
(1S,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-yn-1-ol

: 62-23-7
4-nitro-benzoic acid

: 1265177-86-3
(1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate

Guidance literature:: With triphenylphosphine; diisopropyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 2.16667h; Inert atmosphere;
DOI:10.1021/ol1030074

Reference yield:

: 1070-66-2
2-n-butylacrolein

: 1265177-86-3
(1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dimethyl zinc(II) / toluene / 1.5 h / 20 °C / Inert atmosphere

1.2: 0.17 h / 20 °C / Inert atmosphere

2.1: triethyl borane; oxygen; tri-n-butyl-tin hydride / toluene / 24 h / Air atmosphere

2.2: 0.33 h / -78 - 0 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

4.1: dichloro bis(acetonitrile) palladium(II); triphenyl-arsane; triethylamine / N,N-dimethyl-formamide / 16 h / 130 °C / Inert atmosphere

5.1: methanol; potassium carbonate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

6.1: n-butyllithium / tert-butyl methyl ether / 1.25 h / -90 - 0 °C / Inert atmosphere

6.2: 4.25 h / -90 °C / Inert atmosphere

6.3: -90 - 20 °C / Inert atmosphere

7.1: triphenylphosphine; diisopropyl-carbodiimide / tetrahydrofuran / 2.17 h / 0 - 20 °C / Inert atmosphere

With methanol; dichloro bis(acetonitrile) palladium(II); n-butyllithium; triethyl borane; triphenyl-arsane; dimethyl zinc(II); oxygen; tri-n-butyl-tin hydride; potassium carbonate; triethylamine; triphenylphosphine; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; toluene; 4.1: Stille coupling / 7.1: Mitsunobu reaction;
DOI:10.1021/ol1030074

Reference yield:

: 1265177-79-4
(S,Z)-4-iodo-6-methylene-1-(triethylsilyl)dec-3-en-1-yn-5-ol

: 1265177-86-3
(1R,6S,E)-6-(tert-butyldimethylsilyloxy)-1-((2R,5R)-5-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydrofuran-2-yl)-5-methyl-7-methyleneundec-4-en-2-ynyl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: dichloro bis(acetonitrile) palladium(II); triphenyl-arsane; triethylamine / N,N-dimethyl-formamide / 16 h / 130 °C / Inert atmosphere

3.1: methanol; potassium carbonate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

4.1: n-butyllithium / tert-butyl methyl ether / 1.25 h / -90 - 0 °C / Inert atmosphere

4.2: 4.25 h / -90 °C / Inert atmosphere

4.3: -90 - 20 °C / Inert atmosphere

5.1: triphenylphosphine; diisopropyl-carbodiimide / tetrahydrofuran / 2.17 h / 0 - 20 °C / Inert atmosphere

With methanol; dichloro bis(acetonitrile) palladium(II); n-butyllithium; triphenyl-arsane; potassium carbonate; triethylamine; triphenylphosphine; diisopropyl-carbodiimide; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; N,N-dimethyl-formamide; 2.1: Stille coupling / 5.1: Mitsunobu reaction;
DOI:10.1021/ol1030074