Technology Process of 1,3-bis(hydroxymethyl)-5-(methoxymethoxy)benzene
There total 5 articles about 1,3-bis(hydroxymethyl)-5-(methoxymethoxy)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 20 ℃;
for 6h;
DOI:10.1002/adsc.201600421
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / Inert atmosphere; Schlenk technique
1.2: 3 h / 20 °C / Inert atmosphere; Schlenk technique
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C / Reflux; Inert atmosphere; Schlenk technique
With
lithium aluminium tetrahydride; sodium hydride;
In
tetrahydrofuran; mineral oil;
DOI:10.1002/chem.201400157
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / conc. H2SO4 / 24 h / Heating
2: 85 percent / LiAlH4 / tetrahydrofuran / 12 h / Heating
3: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) DMF, RT, 12 h
With
lithium aluminium tetrahydride; sulfuric acid; sodium hydride;
In
tetrahydrofuran;
DOI:10.1021/ja9725256
